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Comportamiento del pimiento en inoculaci贸n artificial frente al ToMV (virus del Mosaico del Tomate)
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Fetal undernutrition induces resistance artery remodeling and stiffness in male and female rats independent of hypertension
Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance
artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces
resistance artery remodeling and the relationship with hypertension. Sprague鈥揇awley dams were
fed ad libitum (Control) or with 50% of control intake between days 11 and 21 of gestation (maternal
undernutrition, MUN). In six-month-old male and female offspring we assessed blood pressure
(anesthetized and tail-cuff); mesenteric resistance artery (MRA) structure and mechanics (pressure
myography), cellular and internal elastic lamina (IEL) organization (confocal microscopy) and plasma
MMP-2 and MMP-9 activity (zymography). Systolic blood pressure (SBP, tail-cuff) and plasma
MMP activity were assessed in 18-month-old rats. At the age of six months MUN males exhibited
significantly higher blood pressure (anesthetized or tail-cuff) and plasma MMP-9 activity, while MUN
females did not exhibit significant differences, compared to sex-matched controls. MRA from
6-month-old MUN males and females showed a smaller diameter, reduced adventitial, smooth
muscle cell density and IEL fenestra area, and a leftward shift of stress-strain curves. At the age of
eighteen months SBP and MMP-9 activity were higher in both MUN males and females, compared to
sex-matched controls. These data suggest that fetal undernutrition induces MRA inward eutrophic
remodeling and stiffness in both sexes, independent of blood pressure level. Resistance artery
structural and mechanical alterations can participate in the development of hypertension in aged
females and may contribute to adverse cardiovascular events associated with low birth weight in
both sexesThis research was funded by Ministerio de Ciencia, Inovaci贸n y Universidades (Spain), grant
number RTI2018-097504-B-I0